Sertraline and Phenytoin Drug Interaction in a Geriatric Patient

This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient. Among other medications, he was also taking phenytoin. The medical team concluded that the cause of the patient’s lethargy and confusion was a drug interaction between sertraline and phenytoin. Phenytoin was held, while the sertraline was slowly tapered to discontinuation. The patient’s symptoms resolved soon thereafter. Future research is needed to better guide clinicians in appropriate selection, dosing, and monitoring of selective serotonin reuptake inhibitors with concomitant phenytoin use.Key words: phenytoin, sertraline, SSRIs, drug interactio

Equivariant differential characters and symplectic reduction

We describe equivariant differential characters (classifying equivariant circle bundles with connections), their prequantization, and reduction

Non-Gaussian velocity distributions in excited granular matter in the absence of clustering

The velocity distribution of spheres rolling on a slightly tilted rectangular two dimensional surface is obtained by high speed imaging. The particles are excited by periodic forcing of one of the side walls. Our data suggests that strongly non-Gaussian velocity distributions can occur in dilute granular materials even in the absence of significant density correlations or clustering. When the surface on which the particles roll is tilted further to introduce stronger gravitation, the collision frequency with the driving wall increases and the velocity component distributions approach Gaussian distributions of different widths.Comment: 4 pages, 5 figures. Additional information at http://physics.clarku.edu/~akudrolli/nls.htm

Polymers pushing Polymers: Polymer Mixtures in Thermodynamic Equilibrium with a Pore

We investigate polymer partitioning from polymer mixtures into nanometer size cavities by formulating an equation of state for a binary polymer mixture assuming that only one (smaller) of the two polymer components can penetrate the cavity. Deriving the partitioning equilibrium equations and solving them numerically allows us to introduce the concept of "polymers-pushing-polymers" for the action of non-penetrating polymers on the partitioning of the penetrating polymers. Polymer partitioning into a pore even within a very simple model of a binary polymer mixture is shown to depend in a complicated way on the composition of the polymer mixture and/or the pore-penetration penalty. This can lead to enhanced as well as diminished partitioning, due to two separate energy scales that we analyse in detail.Comment: 10 pages, 6 figure

The XMM-Newton Wide field survey in the COSMOS field: redshift evolution of AGN bias and subdominant role of mergers in triggering moderate luminosity AGN at redshift up to 2.2

We present a study of the redshift evolution of the projected correlation function of 593 X-ray selected AGN with I_AB<23 and spectroscopic redshifts z<4, extracted from the 0.5-2 keV X-ray mosaic of the 2.13 deg^2 XMM-COSMOS survey. We introduce a method to estimate the average bias of the AGN sample and the mass of AGN hosting halos, solving the sample variance using the halo model and taking into account the growth of the structure over time. We find evidence of a redshift evolution of the bias factor for the total population of XMM-COSMOS AGN from b(z=0.92)=2.30 +/- 0.11 to b(z=1.94)=4.37 +/- 0.27 with an average mass of the hosting DM halos logM [h^-1 M_sun] ~ 13.12 +/- 0.12 that remains constant at all z < 2. Splitting our sample into broad optical lines AGN (BL), AGN without broad optical lines (NL) and X-ray unobscured and obscured AGN, we observe an increase of the bias with redshift in the range z=0.7-2.25 and z=0.6-1.5 which corresponds to a constant halo mass logM [h^-1 M_sun] ~ 13.28 +/- 0.07 and logM [h^-1 M_sun] ~ 13.00 +/- 0.06 for BL /X-ray unobscured AGN and NL/X-ray obscured AGN, respectively. The theoretical models which assume a quasar phase triggered by major mergers can not reproduce the high bias factors and DM halo masses found for X-ray selected BL AGN with L_BOL ~ 2e45 erg s^-1. Our work extends up to z ~ 2.2 the z <= 1 statement that, for moderate luminosity X-ray selected BL AGN, the contribution from major mergers is outnumbered by other processes, possibly secular such as tidal disruptions or disk instabilities.Comment: 16 emulateapj pages, 18 figures and 3 tables. Accepted for the publication in The Astrophysical Journa

Testing Convolutional Neural Networks for finding strong gravitational lenses in KiDS

Convolutional Neural Networks (ConvNets) are one of the most promising methods for identifying strong gravitational lens candidates in survey data. We present two ConvNet lens-finders which we have trained with a dataset composed of real galaxies from the Kilo Degree Survey (KiDS) and simulated lensed sources. One ConvNet is trained with single \textit{r}-band galaxy images, hence basing the classification mostly on the morphology. While the other ConvNet is trained on \textit{g-r-i} composite images, relying mostly on colours and morphology. We have tested the ConvNet lens-finders on a sample of 21789 Luminous Red Galaxies (LRGs) selected from KiDS and we have analyzed and compared the results with our previous ConvNet lens-finder on the same sample. The new lens-finders achieve a higher accuracy and completeness in identifying gravitational lens candidates, especially the single-band ConvNet. Our analysis indicates that this is mainly due to improved simulations of the lensed sources. In particular, the single-band ConvNet can select a sample of lens candidates with $\sim40\%$ purity, retrieving 3 out of 4 of the confirmed gravitational lenses in the LRG sample. With this particular setup and limited human intervention, it will be possible to retrieve, in future surveys such as Euclid, a sample of lenses exceeding in size the total number of currently known gravitational lenses.Comment: 16 pages, 10 figures. Accepted for publication in MNRA

Reusable Agena study. Volume 2: Technical

The application of the existing Agena vehicle as a reusable upper stage for the space shuttle is discussed. The primary objective of the study is to define those changes to the Agena required for it to function in the reusable mode in the 100 percent capture of the NASA-DOD mission model. This 100 percent capture is achieved without use of kick motors or stages by simply increasing the Agena propellant load by using optional strap-on-tanks. The required shuttle support equipment, launch and flight operations techniques, development program, and cost package are also defined

Two Late Quaternary Pollen Records from South-Central Alaska

Pollen records from Wonder and Ten Mile lakes, located at aititudinal treeline to the north and south of the Alaska Range respectively, document the vegetation history of a portion of the southern Alaskan boreal forest. The new pollen diagrams indicate a Betula shrub tundra, preceded at Wonder Lake by a sparse herb tundra, which characterized these two areas during latest Wisconsinan times. Populus was in the vicinity of Ten Mile Lake ca. 10,000 BP, but was apparently absent from Wonder Lake. Picea glauca grew at or near Ten Mile Lake by 9100 BP, with P. mariana becoming important ca. 7000 BP. The first forests at Wonder Lake were also dominated by P. glauca and followed by increased numbers of P. mariana. The timing of forest establishment at Wonder Lake is uncertain due to problematic radiocarbon dates. Alnus appears to be common in both regions by ca. 7000 BP. These records suggest that paleo-vegetational reconstructions are more difficult for the southern than northern boreal forests in Alaska because of greater topographic diversity, difficulties with over-representation of some pollen taxa, and problems with radiocarbon dating. Despite these concerns, available data from south-central Alaska suggest that southern and northern forests differ in their vegetational histories. Such differences, when related to temperature fluctuations that have been postulated for the Holocene, imply that the Alaskan boreal forest may not respond uniformly to future global warming.Les inventaires polliniques de Wonder Lake et de Ten Mile Lake, situés à la limite altitudinale des arbres au nord et au sud de la chaîne de l'Alaska permettent de reconstituer l'histoire de la végétation d'une portion de la forêt boréale du sud de l'Alaska. Les nouveaux diagrammes polliniques montrent une toundra arbustive à Betula, précédée au Wonder Lake par une toundra herbacée clairsemée, à la fin du Wisconsinien. Vers 10 000 BP, Populus était dans les environs du Ten Mile Lake, mais était apparamment absent du Wonder Lake. Picea glauca croissait autour du Ten Mile Lake à 9100 BP et P. mariana prenait de l'importance vers 7000 BP. Au Wonder Lake, les premières forêts ont également été dominées par P. glauca, puis par un nombre croissant de P. mariana. La chronologie de !'afforestation est incertaine en raison de datations au radiocarbone douteuses. Alnus semble être une espèce courante dans les deux régions vers 7000 BP. Les inventaires indiquent que la reconstitution de la paléovégétation est plus difficile à faire pour les forêts méridionales que septentrionales de l'Alaska, en raison de la plus grande diversité topographique, la sur-représentation de certains taxons et des problèmes de radio-datation. Les données indiquent tout de même que l'histoire de la végétation des forêts diffèrent au nord et au sud. Ces différences, mises en relation avec les fluctuations de températures présumées de l'Holocène, laissent croire que la forêt de l'Alaska ne répondra pas nécessairement de façon uniforme à un réchauffement climatique éventuel.DbiJibneBbie aiiarpa.viMbi ocaaKOB 03ep Baeae n TeHMaRJi, pacnojioxeHiibix B6JIII3H Bepxiiert rpaiiMUbi Jieca Ha ceBepe H wre A/iflCKiiHCKoro xpeôîa, OTpaacaioT ncropnio pacTHTejibHOCTH KOKIIOH lacr" Sopea/ibHoro jieca AJIBCKH. HoBbie ribiJibuebe anarpaMMbi iiOKaabiBaioT, HTO KycTapmiKOBOfi 6epr30B0fi TyHApe, xapaKTepiioft aJifl 3TMX aByx TeppiiTopufl B Teieime no3iuiero BiicKoiicmia, npemuecTBOBajia B oTaoaceiinnx 03. Banae 6emiaH TpaBHHUCTHa iyHapa. Populus iipopn3parra.n B otcpecruocnix 03. Teii.vianji 10000 /J.H., HO, JlO-BIUHMOMy, OTCyTCTBOBaa B pafione 03. BaHae. 9100 JI.H. B panoHe 03. Tenvianj] H.11I B iienocpeacrBeimoH 6/IH30CTH OT iiero npoH3pacTajia Picea glauca, KOTopan BMepTe c Picea mariana nrpaeT 3Ha'iiiTe/ibnyio pojib B codaBe pacTHTeJibHOCTM OKO/IO 7000 .i.n. B nepBbix Jiecax B paflone 03. BaHae TaKjKe aoMiiiuipoBajia Picea glauca, 110 3aTe,vi pojib Picea mariana iiaHimaeT B03pacacTaTb. Bpe.viH noflB/ieiiHfl jiecoB B panone 03. Banae uoKaiie ycraiiaBJiiiBaeTca iiaaeacHo paaiioyr-jiepoaiibiM McroaoM. Alnus o6pa3yer cooBiuecTBa B06011X pafioiiax OKOJIO 7000 JI.H. nojiyieiuibie aaiiHbie cBiiaeTejibCTByioT 0 TOM, HTO peKoiicTpyKniifl pacTiiTejibiiocTH 6yaer 6ojieecjio>KHon aJin lOîKHbix, ieM aJifl ceaepiibix 6opeajibiibix JiecoB AJIHCKH 1133a SHa'iinejibiioro TonorpafpimecKoro iiecxoacTBa,3aTpyaiieiii!Ji B iiHTepnpeTaumi neKOTopwx nbijibneitbix TaKCOHOB, npoGjieM c paanoyrjiepoaiibiM aaTHpBaiine.M. HeavioTpa tia 3TH npo6jieivibi, nojicpieHHbie aaHiibie noKa3biaiOT, HTO fjopeajibiibie Jieca 11a wre 11 ceBepe ioaciion iacni UetiTajibiion AJIHCKH wweioT pa3Jiiiiyio iiCTopnio. TaKiie pa3Jinmtfl, cBfl3xaiuibie c n3MeiieiijiflMii 3eMJiepaTyp B Teieiuie ro.'ioueiia, cBiiae-Te.TbCTByioT, HTO 6opeajibiibiri Jiec AJIHCKH ,vioxer ne OTBenaTb cienapnio rjio6aJibiioro noTen.ieiina u SyaymeM